Research update: Acupuncture, CGRP and a possible mechanism for hot flushes

November 25, 2011 · by Sean Heneghan · Acupuncture News, Research

CGRP (Calcitonin gene related peptide) is a vasodilating peptide which when released by a nerve ending increases blood flow into tissues. The physiologist and acupuncturist Thomas Lundeberg has demonstrated previously that the sensory stimulation of acupuncture increases the levels of CGRP in the saliva of patients with xerostomia (dry mouth) and could be one of the factors that contribute to the effect of acupuncture.

In this recent piece, Swedish researchers have been investigating the effect of acupuncture for hot flushes and postulate that the heat loss experienced by some patients may be once again mediated by release of CGRP which is also a sweat gland activator as well as a potent vasodilator. It’s also known that CGRP is influenced by the body’s opioid system which acupuncture has been shown to affect. The research could be a further useful step in piecing together the complex physiological cascade that follows acupuncture stimulation, and more evidence of the ongoing efforts to reconceptualise acupuncture’s effects in terms of modern scientific theory. More details of the study can be found here

Incidentally this week also saw further positive research looking at acupuncture for relieving the side effects of radiation induced dry mouth in patients with cancer.

 

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